詳細內容： 摘要 目的：綜述3D生物打印支架材料的研究進展和應用。方法：應用計算機檢索PubMed數據庫關于3D生物打印支架材料的文章，檢索詞為“3D bioprinting, scaffold”。結果與結論：3D生物打印技術具有快速成型、精確控制等特點，而且可以應用于個性化治療。天然材料和復合材料可制備成生物墨水用于3D生物打印，通過化學修飾和交聯、多種材料復合可提高材料力學和生物性能。利用3D生物打印可以構
造精密、復雜的組織結構。在再生醫學領域，3D生物打印有廣闊的發展前景。
關鍵詞： 3D 生物打??；組織工程；支架材料；生物墨水
中圖分類號：R318.08 文獻標識碼：A 文章編號：1002-7777(2018)10-1406-06
doi:10.16153/j.1002-7777.2018.10.015
Research Progress of Scaffold Materials for 3-Dimensional Bioprinting
Shi Jianfeng, Wang Han, Zhao Lei, Han Qianqian*
, Wang Chunren*
(National Institutes for Food and Drug Control, Beijing 102629, China)
Abstract Objective: To review research progress and application of scaffold materials for 3-dimensional (3D) bioprinting. Methods: A computer-based retrieval was performed to search articles addressing scaffold materials for 3D bioprinting published in PubMed database by using the keywords of “bioprinting”, “scaffold”. Result and
Conclusion: The 3D bioprinting possesses the characteristics of rapid prototyping and precise control and can be applied to personalized treatments. Natural and synthetic materials can be used to prepare bioink for the 3D bioprinting. The mechanical and biological properties of the materials can be improved by chemical modification and cross-linking. Complex and precise tissue structure can be fabricated by the 3D bioprinting. It is believed that the 3D bioprinting has a great prospect in the field of regenerative medicine.
Keywords： 3D bioprinting; tissue engineering; scaffold material; bioink
